Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap

Iliya D. Stoev; Benjamin Seelbinder; Elena Erben; Nicola Maghelli; Moritz Kreysing

doi:10.1186/s43593-021-00007-7

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Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap

eLight Vol. 1, Issue 1, Pages: 1-7(2021)

RESEARCH ARTICLE | Updated：2021-12-10

- Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap
- Affiliations：
  
  Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307Dresden, Germany
  Centre for Systems Biology, Pfotenhauerstraße 108, 01307Dresden, Germany
  Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany
- Author bio：
  
  *kreysing@mpi-cbg.de
- Funds：
- DOI：10.1186/s43593-021-00007-7
  CLC：
- Published：2021-12，
  
  Published Online：08 December 2021，
  
  Received：23 September 2021，
  
  Revised：22 October 2021，
  
  Accepted：23 October 2021
- Accepted：
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Iliya D. Stoev, Benjamin Seelbinder, Elena Erben, et al. Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap. [J]. eLight, 2021,1(1):1-7.
DOI：

Iliya D. Stoev, Benjamin Seelbinder, Elena Erben, et al. Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap. [J]. eLight, 2021,1(1):1-7. DOI： 10.1186/s43593-021-00007-7.

摘要

Abstract

The use of optical tweezers to measure forces acting upon microscopic particles has revolutionised fields from material science to cell biology. However

despite optical control capabilities

this technology is highly constrained by the material properties of the probe

and its use may be limited due to concerns about the effect on biological processes. Here we present a novel

optically controlled trapping method based on light-induced hydrodynamic flows. Specifically

we leverage optical control capabilities to convert a translationally invariant topological defect of a flow field into an attractor for colloids in an effectively one-dimensional harmonic

yet freely rotatable system. Circumventing the need to stabilise particle dynamics along an unstable axis

this novel trap closely resembles the isotropic dynamics of optical tweezers. Using magnetic beads

we explicitly show the existence of a linear force-extension relationship that can be used to detect femtoNewton-range forces with sensitivity close to the thermal limit. Our force measurements remove the need for laser-particle contact

while also lifting material constraints

which renders them a particularly interesting tool for the life sciences and engineering.

关键词

Keywords

Force measurementsOptofluidicsHydrodynamic trapThermoviscous flows

references

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