Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content

Jiawei Shi; Mingsheng Li; Huajun Tang; Jiqiang Kang; Najia Sharmin; Amir Rosenthal; Kenneth K. Y. Wong

doi:10.1186/s43593-022-00014-2

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Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content

eLight Vol. 2, Issue 1, (2022)

LETTER | Updated：2024-09-28

- Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content
- Affiliations：
  
  Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China
  Department of Electrical Engineering, Technion–Israel Institute of Technology, Technion City, 32000Haifa, Israel
  Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong, China
- Author bio：
  
  *kywong@eee.hku.hk
- Funds：
- DOI：10.1186/s43593-022-00014-2
  CLC：
- Published：2022-12，
  
  Published Online：26 April 2022，
  
  Received：10 June 2021，
  
  Revised：26 September 2021，
  
  Accepted：23 March 2022
- Accepted：
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Jiawei Shi, Mingsheng Li, Huajun Tang, et al. Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content. [J]. eLight, 2022,2(1).
DOI：

Jiawei Shi, Mingsheng Li, Huajun Tang, et al. Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content. [J]. eLight, 2022,2(1). DOI： 10.1186/s43593-022-00014-2.

摘要

Abstract

Water plays a vital role in biological metabolism and it would be essential to trace the water content non-invasively

such as leveraging the vibrational absorption peak of the O–H bond. However

due to the lack of an efficient laser source

it was challenging to image the water content in the deep tissue with micron-level spatial resolution. To address this problem

we develop a high-power hybrid optical parametrically-oscillating emitter (HOPE) at 1930 nm

at which the vibrational absorption peak of the O–H bond locates. The maximum pulse energy is over 1.74 μJ with a pulse repetition rate of 50 kHz and a pulse width of 15 ns. We employ this laser source in the optical-resolution photoacoustic microscopy (OR-PAM) system to image the water content in the phantom and the biological tissue in vitro. Our 1930-nm OR-PAM could map the water content in the complex tissue environment at high spatial resolution

deep penetration depth

improved sensitivity

and suppressed artifact signal of the lipid.

关键词

Keywords

Fiber optical parametric oscillatorThulium-doped fiber laserPhotoacoustic microscopy

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