High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation

Wenyu Peng; Zhi Zhu; Jing Lou; Kun Chen; Yuanming Wu; Chao Chang

doi:10.1186/s43593-023-00048-0

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High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation

eLight Vol. 3, Issue 1, (2023)

RESEARCH ARTICLE | Updated：2024-09-25

- High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation
- Affiliations：
  
  Department of Biochemistry and Molecular Biology, Shaanxi Provincial Key Laboratory of Clinic Genetics, School of Basic Medicine, Air Force Medical University, Xi'an 710032, China
  Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China
  Key Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
  Department of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, School of Basic Medicine, Air Force Medical University, Xi'an 710032, China
  School of Physics, Peking University, Beijing 100871, China
- Author bio：
  
  *Zhi Zhuzhuzhi@usst.edu.cn
  Yuanming Wuwuym@fmmu.edu.cn
  Chao Changgwyzlzssb@pku.edu.cn
- Funds：
- DOI：10.1186/s43593-023-00048-0
  CLC：
- Published：2023，
  
  Published Online：01 August 2023，
  
  Received：26 February 2023，
  
  Revised：02 April 2023，
  
  Accepted：14 May 2023
- Accepted：
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Wenyu Peng, Zhi Zhu, Jing Lou, et al. High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation. [J]. eLight, 2023,3(1).
DOI：

Wenyu Peng, Zhi Zhu, Jing Lou, et al. High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation. [J]. eLight, 2023,3(1). DOI： 10.1186/s43593-023-00048-0.

摘要

Abstract

The accumulation and deposition of amyloid can cause a variety of neurodegenerative diseases

including Alzheimer's and Parkinson's disease. The degradation or clearance of this accumulation is currently the most widely accepted therapeutic strategy for intervention in these pathologies. Our study on amyloid-β (Aβ) oligomers in vitro revealed that high-frequency terahertz (THz) waves at a specific frequency of 34.88 THz could serve as a physical

efficient

nonthermal denaturation technique to delay the fibrotic process by 80%

as monitored by a thioflavine T (ThT) binding assay and Fourier transform infrared (FTIR) spectroscopy. Additionally

THz waves of this frequency have been shown to have no side effects on normal cells

as confirmed by cell viability and mitochondrial membrane potential assays. Furthermore

molecular dynamic (MD) simulations revealed that the THz waves could resonate with Aβ fibrils

disrupting the dense conformation by breaking the β-sheet structure and promoting the formation of abundant coil and bend structures. This study uses the amyloid of Aβ as an example

and the results will further guide interventions for the accumulation of other amyloids

which may provide new ideas for the remission of related diseases.

关键词

Keywords

references

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