Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap

Iliya D. Stoev; Benjamin Seelbinder; Elena Erben; Nicola Maghelli; Moritz Kreysing

doi:10.1186/s43593-021-00007-7

Your Location：

Home >

Browse articles >

Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap

光：快讯（英文） 2021年1卷第1期页码：1-7

Research Article | Updated：2021-12-10

- Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap
- Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap
- Affiliations：
  
  Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307Dresden, Germany
  Centre for Systems Biology, Pfotenhauerstraße 108, 01307Dresden, Germany
  Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany
- Author bio：
  
  *kreysing@mpi-cbg.de
- Funds：
- DOI：10.1186/s43593-021-00007-7
  中图分类号：
- 纸质出版日期：2021-12，
  
  网络出版日期：2021-12-08，
  
  收稿日期：2021-09-23，
  
  修回日期：2021-10-22，
  
  录用日期：2021-10-23
- Accepted：
Scan QR Code
Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap[J]. 光：快讯（英文）, 2021,1(1):1-7.

Iliya D. Stoev, Benjamin Seelbinder, Elena Erben, et al. Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap[J]. eLight, 2021,1(1):1-7.
Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap[J]. 光：快讯（英文）, 2021,1(1):1-7. DOI： 10.1186/s43593-021-00007-7.

Iliya D. Stoev, Benjamin Seelbinder, Elena Erben, et al. Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap[J]. eLight, 2021,1(1):1-7. DOI： 10.1186/s43593-021-00007-7.

摘要

Abstract

The use of optical tweezers to measure forces acting upon microscopic particles has revolutionised fields from material science to cell biology. However

despite optical control capabilities

this technology is highly constrained by the material properties of the probe

and its use may be limited due to concerns about the effect on biological processes. Here we present a novel

optically controlled trapping method based on light-induced hydrodynamic flows. Specifically

we leverage optical control capabilities to convert a translationally invariant topological defect of a flow field into an attractor for colloids in an effectively one-dimensional harmonic

yet freely rotatable system. Circumventing the need to stabilise particle dynamics along an unstable axis

this novel trap closely resembles the isotropic dynamics of optical tweezers. Using magnetic beads

we explicitly show the existence of a linear force-extension relationship that can be used to detect femtoNewton-range forces with sensitivity close to the thermal limit. Our force measurements remove the need for laser-particle contact

while also lifting material constraints

which renders them a particularly interesting tool for the life sciences and engineering.

关键词

Keywords

Force measurementsOptofluidicsHydrodynamic trapThermoviscous flows

references

E. Erbenet al., Feedback-based positioning and diffusion suppression of particles via optical control of thermoviscous flows. Opt. Express29, 30272-30283 (2021)

F.M. Weinert, J.A. Kraus, T. Franosch, D. Braun, Microscale fluid flow induced by thermoviscous expansion along a traveling wave. Phys. Rev. Lett. 100, 164501 (2008)

F.M. Weinert, D. Braun, Optically driven fluid flow along arbitrary microscale patterns using thermoviscous expansion. J. Appl. Phys. 104, 104701 (2008)

M. Tanyeri, M. Ranka, N. Sittipolkul, C.M. Schroeder, A microfluidic-based hydrodynamic trap: design and implementation. Lab. Chip11, 1786-1794 (2011)

M. Tanyeri, E.M. Johnson-Chavarria, C.M. Schroeder, Hydrodynamic trap for single particles and cells. Appl. Phys. Lett. 96, 224101 (2010)

U.G. Būtaitėet al., Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation. Nat. Commun. 10, 1215 (2019)

Stoev, I. D., Caciagli, A., Xing, Z. & Eiser, E. Using single-beam optical tweezers for the passive microrheology of complex fluids. In: Optical Trapping and Optical Micromanipulation XV vol. 10723 107232D(International Society for Optics and Photonics, 2018).

K. Berg-Sørensen, H. Flyvbjerg, Power spectrum analysis for optical tweezers. Rev. Sci. Instrum. 75, 594-612 (2004)

N. Malagnino, G. Pesce, A. Sasso, E. Arimondo, Measurements of trapping efficiency and stiffness in optical tweezers. Opt. Commun. 214, 15-24 (2002)

A. van der Horst, N.R. Forde, Calibration of dynamic holographic optical tweezers for force measurements on biomaterials. Opt. Express16, 20987-21003 (2008)

H. Felgner, O. Müller, M. Schliwa, Calibration of light forces in optical tweezers. Appl. Opt. 34, 977-982 (1995)

J. Gieseleret al., Optical tweezers—from calibration to applications: a tutorial. Adv. Opt. Photonics13, 74-241 (2021)

P.H. Jones, O.M. Maragò, G. Volpe, Optical Tweezers: Principles and Applications (Cambridge University Press, Cambridge, 2015)

J.C. Loudet, P. Hanusse, P. Poulin, Stokes drag on a sphere in a nematic liquid crystal. Science306, 1525-1525 (2004)

L. Giomi, Ž Kos, M. Ravnik, A. Sengupta, Cross-talk between topological defects in different fields revealed by nematic microfluidics. Proc. Natl. Acad. Sci. 114, E5771-E5777 (2017)

M. Mittaschet al., Non-invasive perturbations of intracellular flow reveal physical principles of cell organization. Nat. Cell Biol. 20, 344-351 (2018)

S.M. Hirschet al., FLIRT: fast local infrared thermogenetics for subcellular control of protein function. Nat. Methods15, 921-923 (2018)

A. Singhal, S. Shaham, Infrared laser-induced gene expression for tracking development and function of single C. elegans embryonic neurons. Nat. Commun. 8, 1-3 (2017)

J.-Y. Tinevezet al., TrackMate: an open and extensible platform for single-particle tracking. Methods115, 80-90 (2017)

P. Kollmannsberger, B. Fabry, BaHigh-force magnetic tweezers with force feedback for biological applications. Rev. Sci. Instrum. 78, 114301 (2007)

FULL TEXT LINK

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

暂无数据