High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation

Wenyu Peng; Zhi Zhu; Jing Lou; Kun Chen; Yuanming Wu; Chao Chang

doi:10.1186/s43593-023-00048-0

Your Location：

Home >

Browse articles >

High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation

光：快讯（英文） 2023年3卷第1期

RESEARCH ARTICLE | Updated：2024-09-25

- High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation
- High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation
- Affiliations：
  
  Department of Biochemistry and Molecular Biology, Shaanxi Provincial Key Laboratory of Clinic Genetics, School of Basic Medicine, Air Force Medical University, Xi'an 710032, China
  Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China
  Key Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
  Department of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, School of Basic Medicine, Air Force Medical University, Xi'an 710032, China
  School of Physics, Peking University, Beijing 100871, China
- Author bio：
  
  *Zhi Zhuzhuzhi@usst.edu.cn
  Yuanming Wuwuym@fmmu.edu.cn
  Chao Changgwyzlzssb@pku.edu.cn
- Funds：
- DOI：10.1186/s43593-023-00048-0
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-08-01，
  
  收稿日期：2023-02-26，
  
  修回日期：2023-04-02，
  
  录用日期：2023-05-14
- Accepted：
Scan QR Code
High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation[J]. 光：快讯（英文）, 2023,3(1).

Wenyu Peng, Zhi Zhu, Jing Lou, et al. High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation[J]. eLight, 2023,3(1).
High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation[J]. 光：快讯（英文）, 2023,3(1). DOI： 10.1186/s43593-023-00048-0.

Wenyu Peng, Zhi Zhu, Jing Lou, et al. High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation[J]. eLight, 2023,3(1). DOI： 10.1186/s43593-023-00048-0.

摘要

Abstract

The accumulation and deposition of amyloid can cause a variety of neurodegenerative diseases

including Alzheimer's and Parkinson's disease. The degradation or clearance of this accumulation is currently the most widely accepted therapeutic strategy for intervention in these pathologies. Our study on amyloid-β (Aβ) oligomers in vitro revealed that high-frequency terahertz (THz) waves at a specific frequency of 34.88 THz could serve as a physical

efficient

nonthermal denaturation technique to delay the fibrotic process by 80%

as monitored by a thioflavine T (ThT) binding assay and Fourier transform infrared (FTIR) spectroscopy. Additionally

THz waves of this frequency have been shown to have no side effects on normal cells

as confirmed by cell viability and mitochondrial membrane potential assays. Furthermore

molecular dynamic (MD) simulations revealed that the THz waves could resonate with Aβ fibrils

disrupting the dense conformation by breaking the β-sheet structure and promoting the formation of abundant coil and bend structures. This study uses the amyloid of Aβ as an example

and the results will further guide interventions for the accumulation of other amyloids

which may provide new ideas for the remission of related diseases.

关键词

Keywords

references

P.H. Nguyen, B.R. Ramamoorthya sahoo et al., Amyloid oligomers: a joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis. Chem. Rev. 121(4), 2545-2647 (2021)

M.I. Vaquer-alicea, J. Diamond, Propagation of protein aggregation in neurodegenerative diseases. Annu. Rev. Biochem. 88, 785-810 (2019)

G. Meisl, S. Michaels, T.C.T. Linse et al., Kinetic analysis of amyloid formation. methods. Mol. Biol. 1779, 181-96 (2018)

J.A. Sawaya, M.R. Hughes, M.P. Rodriguez et al., The expanding amyloid family: structure, stability, function, and pathogenesis. Cell184(19), 4857-4873 (2021)

S. Head, C.C. Hsu, T.M. Bi et al., Alpha-sheet secondary structure in amyloid beta-peptide drives aggregation and toxicity in Alzheimer's disease. Proc. Natl. Acad Sci. USA116(18), 8895-900 (2019)

S. Jokar, S. Khazaei, H. Behnammanesh et al., Recent advances in the design and applications of amyloid-beta peptide aggregation inhibitors for Alzheimer's disease therapy. Biophys. Rev. 11, 901-925 (2019)

T. Kawasaki, Y. Man, V. H. Sugimoto et al., Infrared laser-induced amyloid fibril dissociation: a joint experimental/theoretical study on the GNNQQNY peptide. J. Phys. Chem. B124(29), 6266-6277 (2020)

E.N. Wilson, K.I. Andreasson, TAM-ping down amyloid in Alzheimer's disease. Nat. Immunol. 22(5), 543-544 (2021)

J.M. Long, D.M. Holtman, Alzheimer disease: an update on pathobiology and treatment strategies. Cell179(2), 312-339 (2019)

T.M.A. Busche, B. Hyman, Synergy between amyloid-beta and tau in Alzheimer's disease. Nat. Neurosci. 23(10), 1183-1193 (2020)

P. Saha, S.E.N.N. Tauopathy, A common mechanism for neurodegeneration and brain aging. Mech. Ageing Dev. 178, 72-79 (2019)

S. Brahmachari, A. Paul, D. Segal et al., Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules:mechanistic insights and design rules. Future Med. Chem. 9(8), 797-810 (2017)

LIU G, The conjectures on physical mechanism of vertebrate nervous system. Chin. Sci. Bull. 63(36), 3864-3865 (2018)

K. Wu, C. Qi, Z. Zhu et al., Terahertz wave accelerates DNA unwinding: a molecular dynamics simulation study. J. Phys. Chem. Lett. 11 (17), 7002-7008 (2020)

Y. Li, C. Chang, Z. Zhu et al., Terahertz Wave enhances permeability of the voltage-gated calcium channel. J. Am. Chem. Soc. 143(11), 4311-4318 (2021)

X. Liu, Z. Qiao, Y. Chai et al., Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation. Proc. Natl. Acad. Sci. USA118(10), 2015685118 (2021)

C.M. Vendruscolom Dobson, T.P.J. Knowles, The amyloid phenomenon and its significance in biology and medicine. Cold Spring Harbor Perspect. Biol. 12(2), a033878 (2020)

J. Qian, Y. Cao, Y. Bi et al., Structured illumination microscopy based on principal component analysis. eLight.3(1), 4 (2023)

J. Liu, X.C. Zhang, Terahertz-radiation-enhanced emission of fluorescence from gas plasma. Phys. Rev. Lett. 103(23), 235002 (2009)

J. Liu, J. Dai, S.L. Chin, X.C. Zhang, Broadband terahertz wave remote sensing using coherent manipulation of fluorescence from asymmetrically ionized gases. Nat. Photonics4(9), 627-631 (2010)

F.S. Ruggeri, G. Longo, S. Faggiano et al., Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation. Nat. Commun. 6, 7831 (2015)

L. M. Miller, M. W. Bourassa, R. J. Smith, FTIR spectroscopic imaging of protein aggregation in living cells. Biochim. Biophys. Acta1828(10), 2339-2346 (2013)

T. Moran, S.D. Zanni, How to get insight into amyloid structure and formation from Infrared spectroscopy. J. Phys. Chem. Lett. 5(11), 1984-1993 (2014)

R. Sarroukh, J.M. Goormaghtgh, E. Ruysschaert et al., ATR-FTIR: a "rejuvenated" tool to investigate amyloid proteins. Biochim. Biophys. Acta1828(10), 2328-2338 (2013)

A. Delport, Determining the protein stability of Alzheimer's disease protein, amyloid precursor protein. Protein J.38(4), 419-424 (2019)

Y. Kusumoto, A. Lomakin, D.B. Teplow et al., Temperature dependence of amyloid beta-protein fibrillization. Proc. Natl. Acad. Sci. USA95(21), 12277-12282 (1998)

J. Lou, Y. Jiao, R. Yang et al., Calibration-free, high-precision, and robustterahertz ultrafast metasurfaces for monitoring gastric cancers. Proc. Natl. Acad. Sci. USA119(43), e2209218119 (2022)

W. Peng, S. Chen, D. Kong et al., Grade classification of human glioma using a convolutional neural network based on mid-infrared spectroscopy mapping. J. Biophotonics (2022).

W. Peng, S. Chen, D. Kong et al., Grade diagnosis of human glioma using Fourier transform infrared microscopy and artificial neural network. Spectrochim. Acta, Part A260, 119946 (2021)

W. Peng, J. Yin, J. Ma et al., Identification of hepatocellular carcinoma and paracancerous tissue based on the peak area in FTIR microspectroscopy. Anal. Methods. 14(32), 3115-3124 (2022)

Z. Zhu, C. Chang, Y. Shu et al., Transition to a superpermeation phase of confined water induced by a terahertz electromagnetic wave. J. Phys. Chem. Lett. 11 (1), 256-262 (2019)

T. Sun, Z. Zhu, Light resonantly enhances the permeability of functionalized membranes. J. Membr. Sci. 662, 121026 (2022)

X. Zhao, M. Zhang, Y. Liu et al., Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro. iScience24(12), 103485 (2021)

J. Zhang, Y. He, S. Liang et al., Non-invasive, opsin-free mid-infrared modulation activates cortical neurons and accelerates associative learning. Nat. Commun. 12(1), 2730 (2021)

M.H. Abufadda, A. Erdelyi, E. Pollak et al., Terahertz pulses induce segment renewal via cell proliferation and differentiation overriding the endogenous regeneration program of the earthworm Eisenia andrei. Biomed. Opt. Express12(4), 1947-1961 (2021)

X. Wang, X. Shen, FTIR spectroscopic comparison of serum from lung cancer patients and healthy persons. Spectrochim. Acta. Part A122, 193-197 (2014)

A.K. Kanchi, P.K. Dasamahapatra, Polyproline chains destabilize the Alzheimer's amyloid-beta protofibrils: a molecular dynamics simulation study. J. Mol. Graph Model93, 107456 (2019)

Y. Zou, Z. Qian, Y. Chen et al., Norepinephrine inhibits Alzheimer's amyloid-beta peptide aggregation and destabilizes amyloid-beta protofibrils: a molecular dynamics simulation study. ACS Chem. Neurosci. 10(3), 1585-1594 (2019)

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

暂无数据